Oral Medications: From the Inside Out

Sporanox and Lamisil are the two most frequently used oral antifungals. These medications are very effective (54% to 70% cure rate) because they work by traveling through the blood stream to the infected nail. They protect the newly growing nail from being invaded by fungus and control the current infection until a full-grown healthy nail replaces it. Again, nail growth is slow and fungal infections are stubborn; this treatment takes time. The oral medications need to be taken for 3 to 4 months, but remain active within the body for another 6 to 9 months after the medication is discontinued. The downside of these medications is that they can be somewhat expensive. They may also interact with other medications that are being taken, such as antihistamines, cholesterol lowering drugs, benzodiazepines, or drugs used for peptic ulcers. Before beginning treatment with oral antifungals, a blood test is necessary to monitor the function of your liver. In rare instances, these medications can cause liver disease. Other side effects include headache, taste disturbance, stomach upset, dizziness, and skin rash [8]. Many doctors are combining oral and topical medications to maximize the chance of cure.